Protective Effect of Ocimum Gratissimum Against Lead Induced Histological Changes in Rabbit Liver

Background: Since it is well-established that lead exposure can have negative effects on hematological, biochemical, and hepatic parameters, a significant number of research efforts been focused antioxidants are capable treating as well preventing these alterations. Objective: The purpose this study was to explore the influence Ocimum Gratissimum (OG) extract hemato-biochemical parameters livers adult Wistar rats lead-induced toxicity livers. Method: For aim investigation, total 70 were separated into seven groups, with each group containing 10 rats. Group A acted control group, B received 120 mg/kg lead, C 375 OG. only no treatment. role played by A. Before administering OG dosages 750 D E, respectively, dose administered both groups. In F, participants followed whereas in G, 1,190 ascorbic acid. After conclusion oral treatment, which lasted 21 days, animals slaughtered their blood liver tissues collected for subsequent histological biochemical testing. results tests will be shown following paragraphs. Results: led discovery Control had rise average body weight, but experienced fall weight. findings revealed when compared other treatment levels enzymes such ALT, AST, GGT, ALP considerably higher than groups (p 0.05). analysis degenerative alterations, localized necrosis aggregated inflammatory cells B. These found patients. contrast, tissue Groups D, G treated exhibited ameliorative may seen table below.